Immature squamous metaplasia of esophageal glands associated with squamous cell carcinoma
|Author(s)||L. Verset 1 2, V. Huberty 3, V. Bourgeois 4, A. Lemmers 3, P. Demetter 1|
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(1) Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
(2) Department of Pathology, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium
(3) Department of Gastroenterology, Endoscopy Unit, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium
(4) Department of Gastroenterology, Hôpital André Vésale, CHU Charleroi, Charleroi, Belgium
Background: Esophageal immature squamous metaplasia is hardly reported in the literature. This entity can, however, be misinterpreted as high grade dysplasia or invasive squamous cell carcinoma and hence represent a potential pitfall.
Case presentation: Histopathological examination of a superficial esophageal lesion removed by endoscopic submucosal dissection revealed a squamous cell carcinoma associated with immature squamous cell metaplasia arising from esophageal glands. Immunohistochemical stainings allowed to distinguish malignant from metaplastic cells.
Conclusions: Immunohistochemistry for Ber-EP4 is helpful in making the distinction between esophageal squamous cell carcinoma and immature squamous metaplasia. This can avoid overstaging and overtreatment, especially in early esophageal cancer.
|Keywords: Endoscopic submucosal dissection, immature squamous metaplasia, esophagus|
|The authors declare that they have no conflict of interest.|
© Acta Gastro-Enterologica Belgica.