Volume 89 - 2026 - Fasc.1 - Case series
A little known cause of ischemic colitis
Acute ischemic colitis associated with the use of neuroleptic
agents is a rare but potentially life-threatening condition,
and its true incidence is likely underestimated. The exact
pathophysiological mechanisms underlying this complication
remain poorly understood. Sigmoidoscopy or colonoscopy is
considered the gold standard for diagnosis, although various
imaging modalities can also aid in the diagnostic process.
Preventive measures primarily involve the management
of constipation and the reduction of risk factors. In cases
of suspected neuroleptic-induced ischemic colitis, prompt
adjustments in medication—either through dose reduction
or substitution with alternative antipsychotics—should be
considered. This article presents two cases of ischemic colitis
caused by neuroleptic treatment, emphasizing the critical
importance of early diagnosis and timely intervention.