Volume 85 - 2022 - Fasc.3 - Reviews
Which model of small bowel capsule endoscopy has a better diagnostic yield? A systematic review and meta-analysis
Background and study aims: Small-bowel capsule endoscopy
(SBCE) is a safe and efficient method for diagnosis of small-bowel
diseases. Since its development, different models have appeared.
The aim of this study was to analyze which of the different models
of SBCE has the best diagnostic yield.
Patients and methods: Extensive medical literature research
was reviewed, using MESH terms, searching studies comparing
different SBCE types. We analyzed the diagnostic yield of all the
comparisons and when there were 2 or more studies that compared
the same model of SBCEs, a meta-analysis was performed.
Results: Ten eligible studies including 1065 SBCEs procedures
were identified. The main indication was occult gastrointestinal
bleeding in 9/10 studies. Two of them included anemia, chronic
diarrhea and/or chronic abdominal pain. The indication in one
article was celiac disease. In 9 studies, different types of SBCEs
(MiroCam, Endocapsule, OMOM and CapsoCam) were compared
with PillCam (SB, SB2 and SB3). Three studies compared MiroCam
vs PillCam and CapsoCam vs PillCam, while two studies contrast
Endocapsule vs PillCam. None of the SBCEs show superiority over
PillCam [OR 0.78 (95%CI;0.60-1.01)]. One study compared SBCEs
other than Pillcam (MiroCam vs Endocapsule). Nine studies did
not find statistical differences between SBCEs, one showed better
diagnostic yield of Mirocam compared with PillCam SB3 (p=0.02).
The difference between these SBCE was not replayed in the metaanalysis
[OR 0.77 (95%CI;0.49-1.21)].
Conclusions: Despite the appearance of new SBCE models,
there are no differences in diagnostic yield; therefore, SBCE
endoscopist’s performance should be based on experience and