Volume 64 - 2001 - Fasc.1 - Georges Brohée Prize
The immuno-inflammatory reaction in Crohn's disease and ulcerative colitis: characterisation, genetics and clinical application. Focus on TNFcT
Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-innammatory reaction, on genetic predisposition and on potential clinical application of blood immunoinflammatory markers in these diseases. This paper summarizes some aspects of this work, focusing on TNE Following points are developed: production of TNF by inflamed mucosa, genetic control of TNF production, TNF gene polymorphim in inflammatory bowel disease, and evaluation of serum TNF as a marker of disease activity or evolutivity.
