Tissue effects of anti-TNF therapies
| Journal | Volume 64 - 2001 |
| Issue | Fasc.2 - Symposium |
| Author(s) | G. R. D'Haens |
| Full article |
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| Department of Gastroenterology, University Hospital Leuven, Belgium. |
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TNF-? is a pro-inflammatory cytokine produced by monocytes, macrophages and T cells that can affect proliferation, differentiation and function of virtually every cell type. The biologic effects of TNF-?? include stimulation of the acute phase response, cytotoxicity, cachexia, and potentially lethal shock. Furthermore, TNF-? stimulates IL- I and IL-6 production, expression of adhesion molecules, procoagulant 3 |
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© Acta Gastro-Enterologica Belgica. |