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Duodenal metastasis of breast invasive carcinoma of no special type: a rare presentation

Journal Volume 84 - 2021
Issue Fasc.2 - Letters
Author(s) M. Mascarenhas Saraiva 1 2, T. Ribeiro 1 2, A.R. Coelho 3, R. Silva 3 4, A.C. Real 1 2, G. Macedo 1 4 2
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Full Article
PAGES 379-380
(1) Department of Gastroenterology, Centro Hospitalar Universitário de São João, Porto, Portugal
(2) WGO Training Center, Porto, Portugal
(3) Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal
(4) Faculty of Medicine of the University of Porto, Porto, Portugal

The authors read with attention the case report by Vande Berg and coworkers, published on a previous issue of this journal, describing a rare diagnosis of rectal metastases of an incognito invasive lobular breast carcinoma (ILC), for which immunohistochemistry was decisive (1). Likewise, we share a similarly rare case of gastrointestinal metastases of breast carcinoma (BC), in which immunohistochemistry played a pivotal role.A 55-year-old woman was diagnosed in June 2015 with an Invasive Breast Carcinoma of no-special-type (IBCNST) grade III, human epidermal growth factor receptor 2 (HER2) positive, estrogen and progesterone receptors (ER/PR) negative. Biopsy revealed vascular permeation. Neoadjuvant chemotherapy and trastuzumab preceded surgery, performed in December 2015, followed by radiotherapy and trastuzumab. The patient remained free of disease until 2017, when a right cerebellar lesion was diagnosed as BC metastasis and was treated with stereotactic radiosurgery. In January 2020, the patient presented with a 1-month history of post-prandial vomiting, epigastric pain, anorexia, fatigue, and a 10 kg weight loss. Lab tests were unremarkable, except for small increase in CA-125 and CA-15.3.

The authors declare that they have no conflict of interest.
© Acta Gastro-Enterologica Belgica.