Home » AGEB Journal » Issues » Volume 84" » Fasc.3 - Original articles » Article details

Evaluating the accuracy of three international guidelines in identifying the risk of malignancy in pancreatic cysts: a retrospective analysis of a surgical treated population

Journal Volume 84 - 2021
Issue Fasc.3 - Original articles
Author(s) A.Vanden Bulcke 1, J. Jaekers 2, H. Topal 2, D. Vanbeckevoort 3, V. Vandecaveye 3, T. Roskams 4, B.A. Weynand 4, J. Dekervel 1, E. Van Cutsem 1, H. van Malenstein 1, C. Verslype 1, W. Laleman 1, S. van der Merwe 1
Full article
Full Article
PAGES 443-450
(1) Department of gastroenterology and hepatology, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium
(2) Department of hepatobiliary and pancreatic surgery, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium
(3) Department of radiology, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium
(4) Department of pathology, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium

Background and study aims: The international consensus Fukuoka guideline (Fukuoka ICG), The European evidence-based guideline on pancreatic cystic neoplasms (European EBG) and the American Gastroenterological Association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts (AGA IG) are 3 frequently cited guidelines for the risk stratification of neoplastic pancreatic cysts. The aim of this study was to assess the accuracy of detecting malignant cysts by strictly applying these guidelines retrospectively to a cohort of surgically resected pancreatic cysts.

Patients and methods: 72 resected cysts were included in the analysis. Invasive carcinoma, high grade dysplasia and neuro-endocrine tumour were considered as “malignant cysts” for the purpose of the study.

Results: 32% of the resected cysts were malignant. The analysis showed that the Fukuoka ICG, European EBG and AGA IG had a sensitivity of 66,8%, 95,5%, 80%; a specificity of 26,8%, 11,3%, 43,8%; a positive predictive value of 31,8%, 35%, 47,1% and a negative predicted value of 61,1%, 83,3%, 77,8% respectively. The missed malignancy rate was respectively 11,3%, 1,5%, 7,7% and surgical overtreatment was respectively 48,4%, 59,1%, 34,6%.

Conclusion: In this retrospective analysis, the European EBG had the lowest rate of missed malignancy at the expense of a high number of “unnecessary” resections. The Fukuoka ICG had the highest number of missed malignancy. The AGA IG showed the lowest rate of unnecessary surgery at the cost of a high number of missed malignancy. There is need to develop better biomarkers to predict the risk of malignancy.

Keywords: IPMN, malignancy risk, surgery, overtreatment.

The authors declare that they have no conflict of interest.
© Acta Gastro-Enterologica Belgica.
PMID 34599569