Serum serotonin as a non-invasive marker of portal hypertensive gastropathy in Egyptian patients with HCV-related liver cirrhosis
|Journal||Volume 85 - 2022|
|Issue||Fasc.1 - Original articles|
|Author(s)||A. Marwa Gamaleldin 1, I. Walid Ellakany 2, A. Marwa Saad 3, A. Reham Aboelwafa 4|
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(1) Lecturer of Clinical Pathology, Clinical Pathology department, Faculty of Medicine, Alexandria university, Alexandria, Egypt
(2) Lecturer of Tropical Medicine, Tropical Medicine department, Faculty of Medicine, Alexandria university, Alexandria, Egypt
(3) Assistant professor of internal medicine, Internal Medicine department, Geriatric unit, faculty of Medicine, Alexandria university, Alexandria, Egypt
(4) Assistant professor of clinical pathology, clinical pathology department, Faculty of Medicine, Alexandria university, Alexandria, Egypt
Background and study aims: Portal hypertensive gastropathy (PHG) is an important complication of portal hypertension (PHT) in cirrhotic patients. We aimed in the current study to investigate the validity of serum serotonin as a probable non-invasive marker for PHG in cirrhotic patients with PHT. We conducted this study on 100 HCV-related cirrhotic patients divided into three groups according to their endoscopic findings; group I: patients with no endoscopic signs of PHG; group II: patients with mild PHG; and group III: patients with severe PHG. All subjects had routine laboratory investigations, serum serotonin level using ELISA kits, calculation of Child’s score, abdominal ultrasound, and upper GIT endoscopy.
Results: Serum serotonin was significantly higher in those with PHG than those without (t= 5.128, p <0.001). Moreover, it was significantly higher in patients with severe degree of PHG than those with mild PHG (t=7.357, p<0.001). Furthermore, a significant positive correlation was observed between serum serotonin and Child Pugh score (t=7.357, p<0.001). Roc curve analysis revealed that serum serotonin at a level ? 26.5 ng/ml had a 78.82% sensitivity, 73.33% specificity, and accuracy of 78% to discriminate between those with signs of PHG and those without.
Conclusion: Serum serotonin is a valuable non-invasive marker of PHG in HCV-cirrhotic patients. Furthermore, its serial measurements could be used to monitor disease progression
Keywords: Serotonin, PHG, portal hypertension, HCV, liver cirrhosis.
© Acta Gastro-Enterologica Belgica.