Home » AGEB Journal » Issues » Volume 85" » Fasc.1 - Reviews » Article details

Isolated amyloidosis of the gastro-intestinal tract

Journal Volume 85 - 2022
Issue Fasc.1 - Reviews
Author(s) S. Smeets 1, F. Dedeurwaerdere 2, E. Thomaere 3, B. Houthoofd 3, L. D’Hulst 4, P. Wilmes 5, F. Offner 6, S. De Coninck 7
Full article
Full Article
PAGES 80-84
(1) Gastroenterologist in training, University hospital of Ghent
(2) Department of anatomopathology Sint-Andries hospital Tielt
(3) Department of radiology Sint-Andries hospital Tielt
(4) Department of nuclear medicine Sint-Andries hospital Tielt
(5) Department of oncology Sint-Andries hospital Tielt
(6) Department of hematology University hospital Ghent
(7) Department of gastroenterology Sint-Andries hospital Tielt

Amyloidosis is a very rare condition, which, due to its rarity, is often missed or diagnosed in an advanced stage of the disease, causing significant morbidity and mortality. In this review we describe the existing types of amyloidosis focusing on the gastro-intestinal tract. Amyloidosis occurs when abnormal protein fibrils (amyloid) deposit in the muscularis mucosae. This can cause an array of symptoms ranging from (in order of occurrence): gastro-intestinal bleeding, heartburn, unintentional weight loss, early satiety, constipation, diarrhea, nausea, vomiting and fecal incontinence (1). Treatment is focused on the underlying condition (if any) causing the production and deposition of the abnormal fibrils, in combination of symptomatic treatment.

Keywords: Amyloidosis, gastro-intestinal amyloid deposition.

© Acta Gastro-Enterologica Belgica.
PMID 35304997