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A rare case of paraneoplastic myositis associated with neuroendocrine carcinoma of the pancreas

Journal Volume 85 - 2022
Issue Fasc.4 - Case reports
Author(s) F. Decraene 1, F. Van De Mierop 1
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Full Article
PAGES 640-642
(1) Department of Gastroenterology, GZA Sint-Augustinus, Wilrijk, Belgium

Pancreatic cancer is only rarely associated with myopathy. We present a case of a 69-year-old male with recently diagnosed pancreatic cancer, who presented himself with a paraneoplastic myositis of both legs. MRI and EMG contributed to this diagnosis. Treatment was started with high dose corticosteroids followed by urgent laparoscopic pancreaticoduodenectomy. Postoperatively there was a rapid normalisation of the creatinine kinase levels with gradual increase of the muscle strength. The anatomopathology of the biopsy specimen showed a large cell neuroendocrine carcinoma. Paraneoplastic myositis associated with pancreatic cancer may be treated successfully with cancer specific treatment.

Keywords: pancreatic cancer, myositis, paraneoplastic syndrome, pancreaticoduodenectomy.

© Acta Gastro-Enterologica Belgica.
PMID 35770290