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Hypogammaglobulinemia, a new risk factor for hepatitis B virus reactivation : about two cases.

Journal Volume 86 - 2023
Issue Fasc.3 - Case reports
Author(s) F. de Leuze 1, V. Havelange 2, M-A. van Dievoet 3, Y. Horsmans 1, G. Dahlqvist 1
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Full Article
PAGES 493-494
(1) Hepatogastroenterology unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium
(2) Hematology unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium
(3) Laboratory department, Cliniques universitaires Saint-Luc, Brussels, Belgium

Reactivation of the hepatitis B virus (HBV) with immunosuppressive status has been well established, mainly due to medications such as immunosuppressive therapy like cytotoxic chemotherapy, rituximab and biologic therapy, immunosuppression after solid and bone-marrow transplantation or long-term corticosteroids therapy. We report here two cases of HBV reactivation due to global hypogammaglobulinemia. Regular HBV serologic screening and PCR for HBV-DNA should be applied for each patient with primary immunosuppressive status and history of chronic HBV infection. The necessity of a preemptive treatment remains debated.

Keywords: Hepatitis B reactivation, immunosuppression, hypogammaglobulinemia, common variable immunodeficiency.

The authors declare that they have no conflict of interest.
© Acta Gastro-Enterologica Belgica.
PMID 37814567