Different aspects of immunological profile in patients with Non-Alcoholic Fatty liver disease
| Journal | Volume 87 - 2024 |
| Issue | Fasc.2 - Original articles |
| Author(s) | H.A. Osman 1, M. Tag-Adeen 2, U.M. Abdelaal 3, E. Elgezawy 4, K.A. Nasif 5, A. Nafady 6 |
| Full article |
 PAGES 274-281 VIEW FREE PDF |
| DOI | 10.51821/87.2.12205 |
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Affiliations: (1) Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt
(2) Department of Internal Medicine, Division of Gastroenterology and Hepatology, Qena Faculty of Medicine, South Valley University, Qena, Egypt (3) Department of Internal Medicine, Gastroenterology unit, Sohag University, Egypt (4) Department of Clinical Pathology, faculty of medicine, Assiut University, Egypt (5) Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, KSA, Department of Biochemistry, Faculty of Medicine, Minia University, Egypt (6) Department of Clinical and Chemical Pathology, Qena Faculty of Medicine, South Valley University, Qena, Egypt |
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Background: NAFLD is thought to affect approximately one-fourth of the world’s population. Therefore, we evaluated the role of serum complement and immunoglobulins in the NAFLD pathogenesis. Patients and methods: 200 participants were used in this study, divided into two groups; Group I: 100 NAFLD patients and Group II: 100 healthy volunteers. The diagnosis of NAFLD is based on non-invasive methods, following the EASL guideline 2022. IgG, IgM, IgA, C3, and C4 assays were performed on all participants. Results: When the immunological profiles of patients with NAFLD and healthy controls were compared, it was found that the mean IgA in NAFLD patients was (4.20±5.07), whereas the mean IgA in healthy controls was (2.22±1.05) (P=0.000). Additionally, a significant increase in IgG was found in NAFLD patients (17.08±3.87) compared with healthy controls (11.59±3.34), with a P value of (p<0.001). complement C3 and complement C4 levels significantly increased in nonalcoholic fatty liver disease patients (1.28± 0.61 and 0.40 ± 0.19, respectively), compared to healthy controls (0.90 ±0.27 and 0.30 ±0.12, respectively), with a significant P value (p<0.001 for each). Conclusions: Elevated IgA, IgG, C3 and C4 exist in patients with NAFLD and could be associated with fatty liver development and progression of hepatic fibrosis in patients with NAFLD. Keywords: IgG, IgM, IgA, C3, C4, NAFLD, fibrosis. |
| The authors declare that they have no conflict of interest. |
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© Acta Gastro-Enterologica Belgica. PMID 39210759 |
