Long-term complete remission of two patients with synchronous liver metastasis from pancreatic cancer and underlying BRCA-2 mutation
| Journal | Volume 87 - 2024 |
| Issue | Fasc.4 - Case series |
| Author(s) | L. Crapé 1, K. Geboes 1, K. Kortbeek 2, E. Naert 1, A. Hoorens 1, F. Berrevoet 1, N. Van Heddeghem 3, S. Ribeiro 1 |
| Full article |
 PAGES 521-523 VIEW FREE PDF |
| DOI | 10.51821/87.4.11787 |
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Affiliations: (1) Department of Gastroenterology, UZ Ghent, Ghent, Belgium
(2) Department of Gastroenterology, UZ Brussels, Brussels, Belgium (3) Department of Gastroenterology, ASZ Aalst, Aalst |
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Background: Pancreatic ductal adenocarcinoma (PDAC) has a known poor prognosis. For a select group, those with BRCA mutations, frontline platinum-based therapy and poly (ADPribose) polymerase inhibitors are options that can potentially lead to survival benefit. Patients and methods: We present 2 cases of patients with BRCAmutated pancreatic cancer with liver metastases that achieved a remarkable long-term complete remission on platinum-based chemotherapy. Conclusion: Germline testing for BRCA is important in PDAC because it influences treatment choices that impact survival. Complete responses with chemotherapy alone are rarely observed in metastatic PDAC, but may be seen upon treatment with platinum-based therapy. Keywords: BRCA mutation, liver metastasis, pancreatic carcinoma, case study. |
| The authors declare that they have no conflict of interest. |
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© Acta Gastro-Enterologica Belgica. PMID 39745039 |
