Home » AGEB Journal » Issues » Volume 70" » Fasc.1 - Original articles » Article details

Lamivudine monotherapy and lamivudine plus interferon alpha combination therapy in HBeAg negative chronic hepatitis B not responding to previous inter- feron alpha monotherapy

Journal Volume 70 - 2007
Issue Fasc.1 - Original articles
Author(s) Filiz Akyuz, Sabahattin Kaymakoglu, Kadir Demir, Nevzat Aksoy, Cetin Karaca, Ahmet Danalioglu, Derya Onel, Selim Badur, Fatih Besisik, Yılmaz Cakaloglu, Atilla Okten
Full article
Full Article
(1) Department of Gastroenterohepatology and (2) Department of Microbiology, Istanbul University, Istanbul Medical Faculty.

Background and study aims : To investigate the efficacy of the combined therapy of lamivudine (LAM) plus alpha interferon (IFN) and LAM monotherapy in HBeAg negative chronic hepati- tis B (CHB) patients who were unresponsive to previous IFN monotherapy, and the incidence of YMDD mutations. Patients-Methods: Forty-five HBeAg negative patients were enrolled in this study. 24 of these were treated with LAM (100 mg/day, PO. for 24 months) alone (group 1) and 21 with com- bined therapy (IFN-alpha-2b, 10 MU, tiw, SC, for 6 months plus LAM 100 mg/day, PO. for 24 months) (group 2). Normal alanine aminotransferase values and negativity of HBV DNA (molecular hybridization; Digene, USA) were accepted as treatment response. YMDD variants were analyzed at the end of treatment or when clinical breakthrough was observed (Inno-Lipa Innogenetic kit, Belgium). Results : End of follow-up response rate was 29.2%, by ITT in group 1, 19% in group 2 (p > 0.05). Histological activity index was statistically decreased by LAM monotherapy as compared to com- bination therapy. YMDD mutation rates were 59% in group 1, 62.5% in group 2 (p > 0.05). Conclusions : Additional IFN-alpha therapy to LAM in HBeAg negative CHB not responding to previous IFN-alpha monotherapy does not increase the response rate compared to LAM mono- therapy and does not also decrease the incidence of YMDD muta- tions. (Acta gastroenterol. belg., 2007, 70, 20-24).

© Acta Gastro-Enterologica Belgica.
PMID 17619534