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Changes in bone turnover markers in adolescents with gastroesophageal reflux disease treated with lansoprazole

Journal Volume 85 - 2022
Issue Fasc.4 - Original articles
Author(s) A. Islek 1, N. Erol Kizilelma 2, H. Keskin 2, N. Ozturk 3
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Full Article
PAGES 565-571
(1) Department of Pediatric Gastroenterology, Cukurova University School of Medicine, 01320, Adana, Turkey
(2) Department of Pediatrics, Atatürk University School of Medicine, 25240, Erzurum, Turkey
(3) Department of Medical Biochemistry, Atatürk University School of Medicine, 25240, Erzurum, Turkey.

Background: Proton pump inhibitors (PPIs) have been suggested to lead to bone resorption, while the effects of PPIs on the bone mineral metabolism in children has received only limited attention in literature to date. The present study investigates whether lansoprazole alters bone turnover markers in adolescents with gastroesophageal reflux disease (GERD).

Patients and methods: Included in the study were adolescents aged 16–18 with GERD and a healthy volunteers group. The GERD patient group was treated with lansoprazole 30 mg once daily for eight weeks. The serum calcium, phosphorus, magnesium, alkaline phosphatase (ALP), parathormone (PTH), 25 (OH) vitamin D, osteocalcin and urinary calcium, creatinine, deoxypyridinoline (DPD), collagen type-1 crosslinked C-telopeptide (CTX) and collagen type-1 crosslinked N-telopeptide (NTX) of both groups were studied before and after the end of the treatment.

Results: A comparison of the 30 patients with GERD and the 30 volunteers revealed no significant difference in the serum calcium, phosphorus, magnesium, ALP, urinary calcium/creatinine ratio, 25 (OH) vitamin D and PTH levels measured before and after the lansoprazole treatment, while the osteocalcin, DPD, CTX and NTX values were found to be higher after treatment when compared to those at pre- treatment.

Conclusions: The results of this study reveal that eight weeks of treatment with 30 mg lansoprazole daily increased the bone turnover markers of CTX, NTX, DPD and osteocalcin in adolescents aged 16-18.

Keywords: Bone turnover, collagen type-1 cross linked C-telopeptide, collagen type-1 crosslinked N-telopeptide, deoxypyridinoline, osteocalcin, proton pump inhibitor.

The authors declare that they have no conflict of interest.
© Acta Gastro-Enterologica Belgica.
PMID 36566365