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Nutritional status in hepatic encephalopathy and transjugular intrahepatic portosystemic shunt – TIPS, and strategies to improve the outcomes

Journal Volume 86 - 2023
Issue Fasc.2 - Reviews
Author(s) M.Berenguer 1
Full article
Full Article
PAGES 318-322
(1) Hepatology, Liver Transplantation Unit, IIS La Fe and CIBER-EHD, Hospital Universitari i Politècnic La Fe, Valencia, Spain and Department of Medicine, Universitat de València, Valencia, Spain.

Hepatic encephalopathy (HE) is one of the most severe complications following transjugular intrahepatic portosystemic shunt (TIPS). The identification and treatment of risk factors associated with the development of this complication may reduce the incidence and severity of post-TIPS HE. Several studies have demonstrated that the nutritional status plays a major role in the outcome of the cirrhotic population, particularly those who are decompensated. Although scarce, there are also studies highlighting an association between poor nutritional status, sarcopenia, fragile status, and post-TIPS HE. If these data are confirmed, nutritional support could become a means for decreasing this complication, thereby enhancing the use of TIPs in the treatment of refractory ascites or variceal bleeding. In this review, we will discuss the pathogenesis of HE, the data that supports an association with sarcopenia, nutritional status and frailty and the implications that these conditions have on the use of TIPS in clinical practice.

Keywords: cirrhosis, encephalopathy, transjugular intrahepatic portosystemic shunt, sarcopenia, nutrition, frailty.

© Acta Gastro-Enterologica Belgica.
PMID 37428165