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Albendazole Induced Recurrent Acute Toxic Hepatitis: A Case Report

Journal Volume 80 - 2017
Issue Fasc.2 - Case reports
Author(s) Yılmaz Bilgic, Cengiz Yilmaz, Yasir Furkan Cagin, Yahya Atayan, Nese Karadag, Murat Muhsin Muhip Harputluoglu
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(1) Inonu University, Turgut Ozal Medical Center, Department of Gastroenterology, Malatya, Turkey ; (2) Inonu University, Turgut Ozal Medical Center, Department of Pathology, Malatya, Turkey.

Introduction: Drug induced acute toxic hepatitis can be idiosyncratic. Albendazole, a widely used broad spectrum antiparasitic drug is generally accepted as a safe drug. It may cause asymptomatic transient liver enzyme abnormalities but acute toxic hepatitis is very rare. Case Report : Herein, we present the case of 47 year old woman with recurrent acute toxic hepatitis after a single intake of albendazole in 2010 and 2014. The patient was presented with symptoms and findings of anorexia, vomiting and jaundice. For diagnosis, other acute hepatitis etiologies were excluded. Roussel Uclaf Causality Assessment Method (RUCAM) score was calculated and found to be 10, which meant highly probable drug hepatotoxicity. Within 2 months, all pathological findings came to normal. Result : There are a few reported cases of albendazole induced toxic hepatitis, but at adults, there is no known recurrent acute toxic hepatitis due to albendazole at this certainty according to RUCAM score. Conclusion: Physicians should be aware of this rare and potentially fatal adverse effect of albendazole. (Acta gastroenterol. belg., 2017, 80, 309-311).

© Acta Gastro-Enterologica Belgica.
PMID 29560698