Home » AGEB Journal » Issues » Volume 75" » Fasc.3 - Case series » Article details

Eosinophils in the gastrointestinal tract : friends or foes ?

Journal Volume 75 - 2012
Issue Fasc.3 - Case series
Author(s) A. Straumann, E. Safroneeva
Full article
Full Article
(1) Chairman Swiss Eoe Clinic and Swiss Research Group, CH-4600 Olten, Switzerland ; (2) Institute of Social and Preventive Medicine, University of Bern, CH-3012 Bern, Switzerland.

Eosinophils play an important role in the mucosal immune sys- tem of the gastrointestinal tract under resting and under inflam- matory conditions. Under steady-state conditions, the mucosa of the digestive tract is the only organ harboring a substantial number of eosinophils, which, if need be, get activated and exert several effector and immunoregulatory functions. The precise function of these late- phase inflammatory cells is not yet completely understood. Nevertheless, it has recently been demonstrated that lipopolysac- charides from gram-negative bacteria activate eosinophils to rap- idly release mitochondrial DNA in the extracellular space. Released mitochondrial DNA and eosinophil granule proteins form extracellular structures able to bind and inactivate bacteria. These findings suggest a novel mechanism of eosinophil-mediated innate immune responses that might be important in maintaining the intestinal barrier function.

© Acta Gastro-Enterologica Belgica.
PMID 23082700